IMMUNOHISTOCHEMICAL EXPRESSION OF WILM’S TUMOR (WT1) MARKER IN HISTOLOGICAL GRADES OF ORAL SQUAMOUS CELL CARCINOMA
Wilm’s Tumor 1 (WT1) is a tumor suppressor gene located on the chromosome 11p13 that have been detected in variable neoplasm such as mesotheliomas and primary peritoneal serous and ovarian carcinomas. In this study we are determining the immunohistochemical expression of WT1 in oral squamous cell carcinoma (OSCC). One hundred cases of oral squamous cell carcinoma were considered and diagnosed in Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi. Immunohistochemical marker WT1 were applied on the H/E stained slides. Immunohistochemical expression of WT1 was analyzed on sixty eight cases of well differentiated oral squamous cell carcinoma (WD-OSCC), twenty one cases of moderately differentiated oral squamous cell carcinoma (MD-OSCC) and eleven cases of poorly differentiated oral squamous cell carcinoma (PD-OSCC). Sixty three cases (63%) of OSCC samples demonstrated WT1 immunohistochemical expression with seventy four (74%) cases showing low WT1 expression and twenty six cases showing high WT1 expression. P value 0.024 significantly correlated with the histological grades of OSCC. WT1 is involved in the tumorigenesis of OSCC.